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[115], in a meta-analysis with network pharmacology—a discipline which attempts to understand drug actions and interactions with multiple targets—including ten studies (both RCTs and non-RCTs) involving 576 patients with MASLD, highlighted an association between metformin and reduced triglyceride (TG) levels (mean decrease (MD) = −0.17, 95% CI = −0.26 to −0.08), total cholesterol (MD = −0.29, 95% CI = −0.47 to −0.10), and insulin resistance (MD = −0.42, 95% CI = −0.82 to −0.02)

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